If you're an ISP that hosts webmail for users or a software developer that creates a mail client (MUA), then you should consider adding an Unsubscribe button to the UI. Including an Unsubscribe button for senders with a good reputation will reduce "false positive" spam complaints, reduce customer service requests, and improve the experience for your customers.
It has critical mass now and will make a difference for your users the day its implemented. By implementing the Unsubscribe button as an alternative to the Report Spam button, no additional screen real estate is needed and it remains a one-click command for the user.

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